Role of Rab3a in neurotransmitter and hormone release: a discussion of recent data.
نویسندگان
چکیده
27 I lanson, P. I , . , Otto, I I . , Barton, N. and Jahn, K. (1995) J. I3iol. Chcm. 270, 16955-16961 28 Ilayashi, ‘I.., Yamasaki, S., Naucnburg, S., I l k , ‘1’. and Niemann, 11. (1995) EMRO J. 14, 2317-2325 20 Kec, Y., Idin, R. C., Ilsu, S.-C. and Schellcr, K. 11. ( 1995) Neuron 14, 991 -998 30 Chapman, E:. K., An, S., Barton, N. and Jahn, R. (1994) J . I3iol. Chem. 269, 27427-27432 3 I Koth, I). and Burgoyne, K. I>. (1995) FMlS I xt t .
منابع مشابه
Structural Basis of Rab Effector Specificity Crystal Structure of the Small G Protein Rab3A Complexed with the Effector Domain of Rabphilin-3A
The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state...
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The Rab3 GDP/GTP exchange protein (Rab3 GEP) activates the Rab3 small GTP-binding protein (G protein) family, including Rab3A that is an important member controlling synaptic vesicle trafficking. Here, we examined the role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture. The release probability was markedly reduced in Rab3 GEP-/- neurons, w...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1996